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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-GSDME Rabbit Monoclonal Antibody
KD-Validated Anti-GSDME Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O60443 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4290 |
| Calculated MW | Predicted, 55 kDa; observed, 55 kDa |
| Gene Name | GSDME |
| Aliases | GSDME; Gasdermin E; ICERE-1; DFNA5; Inversely Correlated With Estrogen Receptor Expression 1; DFNA5, Deafness Associated Tumor Suppressor; Non-Syndromic Hearing Impairment Protein 5; Gasdermin-E; Inversely Correlated With Estrogen Receptor Expression; Nonsyndromic Hearing Impairment Protein; Deafness, Autosomal Dominant 5; ICERE1 |
| Immunogen | Recombinant protein of human GSDME |
| Gene ID | 1687 |
|---|---|
| Other Names | Gasdermin-E, Inversely correlated with estrogen receptor expression 1, ICERE-1, Non-syndromic hearing impairment protein 5, Gasdermin-E, N-terminal, GSDME-NT, Gasdermin-E, C-terminal, GSDME-CT, GSDME {ECO:0000303|PubMed:28459430, ECO:0000312|HGNC:HGNC:2810} |
| Name | GSDME {ECO:0000303|PubMed:28459430, ECO:0000312|HGNC:HGNC:2810} |
|---|---|
| Function | [Gasdermin-E]: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis (PubMed:27281216, PubMed:28459430, PubMed:33852854, PubMed:35594856, PubMed:36607699). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:28459430). |
| Cellular Location | [Gasdermin-E, N-terminal]: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6} |
| Tissue Location | Expressed in cochlea (PubMed:9771715). Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta (PubMed:9771715). |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2251
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