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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-LLGL1 Rabbit Monoclonal Antibody
KD-Validated Anti-LLGL1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q15334 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4695 |
| Calculated MW | Predicted, 115 kDa; observed, 130 kDa |
| Gene Name | LLGL1 |
| Aliases | LLGL1; LLGL Scribble Cell Polarity Complex Component 1; Lgl1; Mgl1; DLG4; HUGL; LLGL; Lethal Giant Larvae Homolog 1, Scribble Cell Polarity Complex Component; Lethal(2) Giant Larvae Protein Homolog 1; Human Homolog To The D-Lgl Gene Protein; HUGL-1; HUGL1; LLGL1, Scribble Cell Polarity Complex Component; Lethal Giant Larvae Homolog 1 (Drosophila); Hugl-1 |
| Immunogen | Recombinant protein of human LLGL1 |
| Gene ID | 3996 |
|---|---|
| Other Names | Lethal(2) giant larvae protein homolog 1, LLGL, DLG4, Hugl-1, Human homolog to the D-lgl gene protein, LLGL1, DLG4, HUGL, HUGL1 |
| Name | LLGL1 |
|---|---|
| Synonyms | DLG4, HUGL, HUGL1 |
| Function | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. |
| Cellular Location | Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developing axons (By similarity). |
| Tissue Location | Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI2281
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