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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-TPX2 Rabbit Monoclonal Antibody
KD-Validated Anti-TPX2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9ULW0 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4765 |
| Calculated MW | Predicted, 86 kDa; observed, 98 kDa |
| Gene Name | TPX2 |
| Aliases | TPX2; TPX2 Microtubule Nucleation Factor; HCA519; DIL-2; P100; Hepatocellular Carcinoma-Associated Antigen 519; Targeting Protein For Xklp2; C20orf1; C20orf2; FLS353; Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2; Differentially Expressed In Cancerous And Noncancerous Lung Cells 2; Hepatocellular Carcinoma-Associated Antigen 90; Protein Fls353; DIL2; Restricted Expression Proliferation Associated Protein 100; Restricted Expression Proliferation-Associated Protein 100; TPX2, Microtubule-Associated, Homolog (Xenopus Laevis); Preferentially Expressed In Colorectal Cancer; TPX2, Microtubule-Associated Protein Homolog; Differentially Expressed In Lung Cells; TPX2, Microtubule-Associated, Homolog; Chromosome 20 Open Reading Frame 1; TPX2, Microtubule-Associated; GD:C20orf1; REPP86; HCTP4 |
| Immunogen | A synthesized peptide derived from human TPX2 |
| Gene ID | 22974 |
|---|---|
| Other Names | Targeting protein for Xklp2, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Hepatocellular carcinoma-associated antigen 519, Hepatocellular carcinoma-associated antigen 90, Protein fls353, Restricted expression proliferation-associated protein 100, p100, TPX2, C20orf1, C20orf2, DIL2, HCA519 |
| Name | TPX2 |
|---|---|
| Synonyms | C20orf1, C20orf2, DIL2, HCA519 |
| Function | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764, PubMed:37728657). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation (PubMed:26165940). |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. |
| Tissue Location | Expressed in lung carcinoma cell lines but not in normal lung tissues |
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$ 149.00
$ 499.00
Cat# AGI2286
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