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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-WWOX Rabbit Monoclonal Antibody
KD-Validated Anti-WWOX Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NZC7 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4780 |
| Calculated MW | Predicted, 47 kDa; observed, 40 kDa |
| Gene Name | WWOX |
| Aliases | WWOX; WW Domain Containing Oxidoreductase; SDR41C1; WOX1; FOR; WW Domain-Containing Oxidoreductase; Short Chain Dehydrogenase/Reductase Family 41C Member 1; Fragile Site FRA16D Oxidoreductase; Short Chain Dehydrogenase/Reductase Family 41C, Member 1; WW Domain-Containing Protein WWOX; EC 1.1.1.-; D16S432E; EC 1.1.1; HHCMA56; PRO0128; EIEE28; FRA16D; SCAR12; DEE28 |
| Immunogen | Recombinant protein of human WWOX |
| Gene ID | 51741 |
|---|---|
| Other Names | WW domain-containing oxidoreductase, 1.1.1.-, Fragile site FRA16D oxidoreductase, Short chain dehydrogenase/reductase family 41C member 1, WWOX, FOR, SDR41C1, WOX1 |
| Name | WWOX |
|---|---|
| Synonyms | FOR, SDR41C1, WOX1 |
| Function | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
| Cellular Location | Cytoplasm. Nucleus Mitochondrion. Golgi apparatus. Lysosome Note=Partially localizes to the mitochondria (PubMed:14695174) Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus Localized to the lysosome probably upon binding to VOPP1 (PubMed:30285739). {ECO:0000250, ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:30285739} |
| Tissue Location | Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2287
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