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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-YTHDC2 Rabbit Monoclonal Antibody
KD-Validated Anti-YTHDC2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9H6S0 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB4785 |
| Calculated MW | Predicted, 161 kDa; observed, 160 kDa |
| Gene Name | Ythdc2 |
| Aliases | YTHDC2; YTH N6-Methyladenosine RNA Binding Protein C2; 3'-5' RNA Helicase YTHDC2; YTH Domain Containing 2; DKFZp564A186; FLJ10053; FLJ2194; HYTHDC2; Probable ATP-Dependent RNA Helicase YTHDC2; CsA-Associated Helicase-Like Protein; YTH Domain-Containing Protein 2; EC 3.6.4.13; EC 3.6.1; CAHL |
| Immunogen | Recombinant protein of mouse YTHDC2 |
| Gene ID | 64848 |
|---|---|
| Other Names | 3'-5' RNA helicase YTHDC2, 3.6.4.13, YTH domain-containing protein 2, hYTHDC2, YTHDC2 {ECO:0000303|PubMed:29033321, ECO:0000312|HGNC:HGNC:24721} |
| Name | YTHDC2 {ECO:0000303|PubMed:29033321, ECO:0000312|HGNC:HGNC:24721} |
|---|---|
| Function | 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A- containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:B2RR83}. Cytoplasm, perinuclear region |
| Tissue Location | Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293). |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2288
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