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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Ephrin Receptor B4 Rabbit Monoclonal Antibody
KD-Validated Anti-Ephrin Receptor B4 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P54760 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB1045 |
| Calculated MW | Predicted , 108 kDa , observed , 135 kDa |
| Gene Name | EPHB4 |
| Aliases | EPH Receptor B4; Ephrin Receptor EphB4; HTK; Ephrin Type-B Receptor; MYK1; Soluble EPHB4 Variant 1; Hepatoma Transmembrane Kinase; Soluble EPHB4 Variant 2; Tyrosine-Protein Kinase TYRO11; Soluble EPHB4 Variant 3; TYRO11; Tyrosine-Protein Kinase Receptor HTK; EC 2.7.10.1; EC 2.7.10; EphB4 |
| Immunogen | A synthesized peptide derived from human Eph receptor B4/HTK |
| Gene ID | 2050 |
|---|---|
| Other Names | Ephrin type-B receptor 4, 2.7.10.1, Hepatoma transmembrane kinase, Tyrosine-protein kinase TYRO11, EPHB4, HTK, MYK1, TYRO11 |
| Name | EPHB4 |
|---|---|
| Synonyms | HTK, MYK1, TYRO11 |
| Function | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2299
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