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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-CLPP Rabbit Monoclonal Antibody
KD-Validated Anti-CLPP Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q16740 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 1865 |
| Calculated MW | Predicted, 30 kDa, observed, 26 kDa |
| Gene Name | CLPP |
| Aliases | CLPP; Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit; ATP-Dependent Clp Protease Proteolytic Subunit, Mitochondrial; Endopeptidase Clp; EC 3.4.21.92; ClpP (Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit, E. Coli) Homolog; ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog (E. Coli); ClpP Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit Homolog (E. Coli); ClpP Caseinolytic Peptidase, ATP-Dependent, Proteolytic Subunit Homolog; ClpP Caseinolytic Protease, ATP-Dependent, Proteolytic Subunit Homolog; Putative ATP-Dependent Clp Protease Proteolytic Subunit, Mitochondrial; ATP-Dependent Protease ClpAP (E. Coli), Proteolytic Subunit, Human; ClpP Caseinolytic Peptidase ATP-Dependent, Proteolytic Subunit; ATP-Dependent; Protease ClpAP, Proteolytic Subunit, Human; DFNB81; PRLTS3 |
| Immunogen | A synthesized peptide derived from human CLPP |
| Gene ID | 8192 |
|---|---|
| Other Names | ATP-dependent Clp protease proteolytic subunit, mitochondrial, 3.4.21.92, Caseinolytic mitochondrial matrix peptidase proteolytic subunit {ECO:0000312|HGNC:HGNC:2084}, Endopeptidase Clp, CLPP (HGNC:2084) |
| Name | CLPP (HGNC:2084) |
|---|---|
| Function | Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The ClpXP complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782). Cleaves PINK1 in the mitochondrion (PubMed:22354088). |
| Cellular Location | Mitochondrion matrix |
| Tissue Location | Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney |
Research Areas
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$ 399.20
$ 149.00
Cat# AGI2328
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