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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-AGO3 Rabbit Monoclonal Antibody
KD-Validated Anti-AGO3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9H9G7 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3930 |
| Calculated MW | Predicted, 97 kDa , observed, 97 kDa |
| Gene Name | AGO3 |
| Aliases | AGO3; Argonaute RISC Catalytic Component 3; EIF2C3; Eukaryotic Translation Initiation Factor 2C, 3; Protein Argonaute-3; FLJ12765; HAGO3; HAgo3; Eukaryotic Translation Initiation Factor 2C; Argonaute 3, RISC Catalytic Component; EC 3.1.26.N2; Argonaute 3; Argonaute3; EIF-2C 3; EIF2C 3 |
| Immunogen | A synthesized peptide derived from human EIF2C3 |
| Gene ID | 192669 |
|---|---|
| Other Names | Protein argonaute-3 {ECO:0000255|HAMAP-Rule:MF_03032}, Argonaute3 {ECO:0000255|HAMAP-Rule:MF_03032}, hAgo3, 3.1.26.n2, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, eIF-2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, eIF2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, AGO3, EIF2C3 |
| Name | AGO3 |
|---|---|
| Synonyms | EIF2C3 |
| Function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA- dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). |
| Cellular Location | Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03032, ECO:0000269|PubMed:16081698} |
Research Areas
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$ 399.20
$ 149.00
Cat# AGI2333
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