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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-EHMT2/G9A Rabbit Monoclonal Antibody
KD-Validated Anti-EHMT2/G9A Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | Q96KQ7 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB820 |
| Calculated MW | Predicted, 132 kDa; Observed, 160-170 kDa |
| Gene Name | EHMT2 |
| Aliases | KMT1C; G9A; C6orf3; BAT8; Euchromatic Histone-Lysine N-Methyltransferase; Histone-Lysine N-Methyltransferase EHMT2; Histone H3-K9 Methyltransferase; HLA-B Associated Transcript 8; Lysine N-Methyltransferase 1C; H3-K9-HMTase; Em:AF134726.3; NG36/G9a; NG36; Histone-Lysine N-Methyltransferase, H3 Lysine-9 Specific 3; Chromosome 6 Open Reading Frame 30; Ankyrin Repeat-Containing Protein; G9A Histone Methyltransferase; HLA-B-Associated Transcript 8; EC 2.1.1.367; Protein G9a; EC 2.1.1.-; GAT8 |
| Immunogen | A synthesized peptide derived from human EHMT2/G9A |
| Gene ID | 10919 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase EHMT2, 2.1.1.-, 2.1.1.367, Euchromatic histone-lysine N-methyltransferase 2, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, Lysine N-methyltransferase 1C, Protein G9a, EHMT2, BAT8, C6orf30, G9A, KMT1C, NG36 |
| Name | EHMT2 |
|---|---|
| Synonyms | BAT8, C6orf30, G9A, KMT1C, NG36 |
| Function | Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. |
| Cellular Location | Nucleus. Chromosome. Note=Associates with euchromatic regions (PubMed:11316813). Does not associate with heterochromatin (PubMed:11316813). |
| Tissue Location | Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2359
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