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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Brain derived neurotrophic factor Rabbit Monoclonal Antibody
KD-Validated Anti-Brain derived neurotrophic factor Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P23560 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 3005 |
| Calculated MW | Predicted, 28 kDa , observed, 28 kDa |
| Gene Name | BDNF |
| Aliases | BDNF; Brain Derived Neurotrophic Factor; Brain-Derived Neurotrophic Factor; Neurotrophin; Abrineurin; ANON2; BULN2 |
| Immunogen | A synthesized peptide derived from human BDNF |
| Gene ID | 627 |
|---|---|
| Other Names | Neurotrophic factor BDNF precursor form, proBDNF, Abrineurin, Brain-derived neurotrophic factor, Neurotrophic factor BDNF, BDNF {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:1033} |
| Name | BDNF {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:1033} |
|---|---|
| Function | Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood plasma and in saliva (at protein level) (PubMed:11152678, PubMed:19467646). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI2360
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