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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Fibronectin 1 Rabbit Monoclonal Antibody
KD-Validated Anti-Fibronectin 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P02751 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB1270 |
| Calculated MW | Predicted, 263 kDa ; Observed, 263 kDa |
| Gene Name | FN1 |
| Aliases | Fibronectin1; CIG; Cold-Insoluble Globulin; GFND2; LETS ; FINC; MSF; Migration-Stimulating Factor; Lnc-ABCA12-8; Fibronectin; FN; Epididymis Secretory Sperm Binding Protein; LNC-ABCA12-8; SMDCF; ED-B; GFND; FNZ |
| Immunogen | A synthesized peptide derived from human Fibronectin |
| Gene ID | 2335 |
|---|---|
| Other Names | Fibronectin, FN, Cold-insoluble globulin, CIG, Anastellin, Ugl-Y1, Ugl-Y2, Ugl-Y3, FN1 (HGNC:3778), FN |
| Name | FN1 (HGNC:3778) |
|---|---|
| Synonyms | FN |
| Function | Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted {ECO:0000250|UniProtKB:P11276} |
| Tissue Location | Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level) (PubMed:29777959) Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine (PubMed:17614963). |
Research Areas
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$ 399.20
$ 149.00
Cat# AGI2367
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