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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-HIF 1 β Rabbit Monoclonal Antibody
KD-Validated Anti-HIF 1 β Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P27540 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB660 |
| Calculated MW | Predicted, 87 kDa; Observed, 87 kDa |
| Gene Name | ARNT |
| Aliases | ARNT; Aryl Hydrocarbon Receptor Nuclear Translocator ; BHLHe2; HIF-1beta; Class E Basic Helix-Loop-Helix Protein 2; Hypoxia Inducible Factor 1; Subunit Beta; Dioxin Receptor, Nuclear Translocator; HIF-1-Beta; HIF1-Beta; ARNT1; Hypoxia-Inducible Factor 1, Beta Subunit; Hypoxia-Inducible Factor 1-Beta; ARNT Protein; HIF1BETA; BHLHE2; HIF1B; TANGO |
| Immunogen | A synthesized peptide derived from human HIF-1 beta |
| Gene ID | 405 |
|---|---|
| Other Names | Aryl hydrocarbon receptor nuclear translocator, ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1-beta, HIF-1-beta, HIF1-beta, ARNT (HGNC:700), BHLHE2 |
| Name | ARNT (HGNC:700) |
|---|---|
| Synonyms | BHLHE2 |
| Function | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding (PubMed:34521881). The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'- TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). |
| Cellular Location | Nucleus. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2380
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