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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Cathepsin B Rabbit Monoclonal Antibody
KD-Validated Anti-Cathepsin B Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | P07858 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 1130 |
| Calculated MW | Predicted, 38 kDa , observed, 38 kDa |
| Gene Name | CTSB |
| Aliases | CTSB; Cathepsin B; APP Secretase; Cathepsin B1; EC 3.4.22.1; APPS; CPSB; Keratolytic Winter Erythema (Oudtshoorn Skin Disease); Epididymis Secretory Sperm Binding Protein; Amyloid Precursor Protein Secretase; Cysteine Protease; EC 3.4.22; RECEUP; KWE |
| Immunogen | A synthesized peptide derived from human Cathepsin B |
| Gene ID | 1508 |
|---|---|
| Other Names | Cathepsin B, 3.4.22.1, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB |
| Name | CTSB |
|---|---|
| Synonyms | CPSB |
| Function | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). |
| Cellular Location | Lysosome. Melanosome. Secreted, extracellular space {ECO:0000250|UniProtKB:A1E295}. Apical cell membrane {ECO:0000250|UniProtKB:P10605}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10605}; Extracellular side {ECO:0000250|UniProtKB:P10605}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity) {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:17081065} |
| Tissue Location | Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2398
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