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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KO-Validated Anti-CD55 Rabbit Monoclonal Antibody
KO-Validated Anti-CD55 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P08174 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB435 |
| Calculated MW | Predicted, 41 kDa, observed, 55-80 kDa |
| Gene Name | CD55 |
| Aliases | CD55; CD55 Molecule (Cromer Blood Group); CR; CROM; DAF; TC; CD55 Molecule, Decay AcceleRating Factor For Complement (Cromer Blood Group); Complement Decay-AcceleRating Factor; CD55 Antigen; Decay AcceleRating Factor For Complement (CD55, Cromer Blood Group System); Cromer Blood Group Antigen; Rh Blood Group D Antigen; CHAPLE |
| Immunogen | A synthesized peptide derived from human CD55 |
| Gene ID | 1604 |
|---|---|
| Other Names | Complement decay-accelerating factor, CD55, CD55, CR, DAF |
| Name | CD55 |
|---|---|
| Synonyms | CR, DAF |
| Function | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted [Isoform 5]: Secreted [Isoform 7]: Cell membrane; Lipid-anchor, GPI-anchor |
| Tissue Location | Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI2417
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