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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KO-Validated Anti-SRPK2 Mouse Monoclonal Antibody
KO-Validated Anti-SRPK2 Mouse Monoclonal Antibody
Mouse monoclonal antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | P78362 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2a |
| Clone Names | 25GB660 |
| Calculated MW | Predicted, 78 kDa; observed, 125kDa |
| Gene Name | SRPK2 |
| Aliases | SRPK2; SRSF Protein Kinase 2; SFRS Protein Kinase 2; SFRSK2; Serine/Arginine-Rich Protein-Specific Kinase 2; Serine/Arginine-Rich Splicing Factor Kinase 2; SR-Protein-Specific Kinase 2; SR Protein Kinase 2; EC 2.7.11.1; Serine/Threonine-Protein Kinase SRPK2; Serine Kinase SRPK2 |
| Immunogen | Recombinant protein of human SRPK2 |
| Gene ID | 6733 |
|---|---|
| Other Names | SRSF protein kinase 2, 2.7.11.1, SFRS protein kinase 2, Serine/arginine-rich protein-specific kinase 2, SR-protein-specific kinase 2, SRSF protein kinase 2 N-terminal, SRSF protein kinase 2 C-terminal, SRPK2 {ECO:0000312|EMBL:AAH68547.1} |
| Name | SRPK2 {ECO:0000312|EMBL:AAH68547.1} |
|---|---|
| Function | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing (PubMed:18559500, PubMed:21056976, PubMed:9472028). Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression (PubMed:19592491). This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression (PubMed:21205200). Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation (PubMed:18559500). Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28 (PubMed:18425142). Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). Can mediate hepatitis B virus (HBV) core protein phosphorylation (PubMed:12134018). Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles (PubMed:16122776). |
| Cellular Location | Cytoplasm. Nucleus, nucleoplasm. Nucleus speckle. Chromosome. Note=Shuttles between the nucleus and the cytoplasm (PubMed:19592491, PubMed:21056976, PubMed:21157427) KAT5/TIP60 inhibits its nuclear translocation (PubMed:21157427) Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation (PubMed:19592491). Preferentially localizes across the entire gene coding region (PubMed:28076779). During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorylated POLR2A/RNA polymerase II and helicase DDX23 (PubMed:28076779). |
| Tissue Location | Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2420
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