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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KO-Validated Anti-Protein Regulator Of Cytokinesis 1 Rabbit Monoclonal Antibody
KO-Validated Anti-Protein Regulator Of Cytokinesis 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O43663 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3195 |
| Calculated MW | Predicted, 72 kDa; observed, 72 kDa |
| Gene Name | PRC1 |
| Aliases | PRC1; Protein Regulator Of Cytokinesis 1; ASE1; MAP65; Anaphase Spindle Elongation 1 Homolog (S. Cerevisiae); Anaphase Spindle Elongation 1 Homolog; Protein Regulating Cytokinesis 1 |
| Immunogen | A synthesized peptide derived from human PRC1 |
| Gene ID | 9055 |
|---|---|
| Other Names | Protein regulator of cytokinesis 1 {ECO:0000312|HGNC:HGNC:9341}, PRC1 (HGNC:9341) |
| Name | PRC1 (HGNC:9341) |
|---|---|
| Function | Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). |
| Cellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Midbody. Chromosome Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436) Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105). |
| Tissue Location | Overexpressed in bladder cancer cells (PubMed:17409436). |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2432
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