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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KO-Validated Anti-ARFGEF2 Rabbit Monoclonal Antibody
KO-Validated Anti-ARFGEF2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9Y6D5 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3860 |
| Calculated MW | Predicted, 202 kDa; observed, 230 kDa |
| Gene Name | ARFGEF2 |
| Aliases | ARFGEF2; ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2; BIG2; Brefeldin A-Inhibited Guanine Nucleotide-Exchange Protein 2; ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited); Brefeldin A-Inhibited GEP; ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor; DJ1164I10.1; ARFGEP2; PVNH2 |
| Immunogen | A synthesized peptide derived from human ARFGEF2 |
| Gene ID | 10564 |
|---|---|
| Other Names | Brefeldin A-inhibited guanine nucleotide-exchange protein 2, Brefeldin A-inhibited GEP 2, ADP-ribosylation factor guanine nucleotide-exchange factor 2, ARFGEF2, ARFGEP2, BIG2 |
| Name | ARFGEF2 |
|---|---|
| Synonyms | ARFGEP2, BIG2 |
| Function | Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. |
| Cellular Location | Cytoplasm. Membrane. Golgi apparatus. Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, dendrite Cytoplasmic vesicle. Synapse. Cytoplasm, cytoskeleton. Note=Translocates from cytoplasm to membranes upon cAMP treatment. Localized in recycling endosomes |
| Tissue Location | Expressed in placenta, lung, heart, brain, kidney and pancreas |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI2443
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