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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >    CD15 / FUT4 (Reed-Sternberg Cell Marker) Antibody - With BSA and Azide   

CD15 / FUT4 (Reed-Sternberg Cell Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone FR4A5 ]

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Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22083
Other Accession 2526, 654379
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgM, kappa
Clone Names FR4A5
Calculated MW ~220kDa (Glycoprotein)
Additional Information
Gene ID 2526
Other Names Alpha-(1, 3)-fucosyltransferase 4, 2.4.1.-, ELAM-1 ligand fucosyltransferase, Fucosyltransferase 4, Fucosyltransferase IV, Fuc-TIV, FucT-IV, Galactoside 3-L-fucosyltransferase, FUT4, ELFT, FCT3A
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD15 / FUT4 (Reed-Sternberg Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FUT4 {ECO:0000303|PubMed:29593094}
Function [Isoform Short]: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:29593094, PubMed:1702034, PubMed:1716630). Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6- sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins (PubMed:29593094, PubMed:1716630). Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis (By similarity). In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:1716630, PubMed:11278338).
Cellular Location Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi
Tissue Location [Isoform Short]: Expressed at low levels in bone marrow-derived mesenchymal stem cells.
Research Areas
Citations (0)

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CD15 plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. In addition, CD15 is expressed in Reed-Sternberg cells and some epithelial cells. CD15 antibody is very useful in the identification of Hodgkin’s disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes which otherwise have a quite distinct histological appearance.


Bettelheim, P., et al., Cluster Report: CD15, in : Knapp, W., et al. (eds), Leucocyte Typing IV, Oxford Univ. Press, pp 798-799. | Hogg, N., et al., Myeloid antigens: new and previously defines clusters, in: McMichae, A.J., et al (eds), Leucocyte Typing III, Oxford Univ. Press, pp 576-602

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$ 219.00
$ 499.00
Cat# AH11272-20
Availability: 3-5 days
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