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CDw75 (B-Cell Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone LN-1 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P15907 |
| Other Accession | 6480, 207459 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgM, kappa |
| Clone Names | LN-1 |
| Calculated MW | 46kDa |
| Gene ID | 6480 |
|---|---|
| Other Names | Beta-galactoside alpha-2, 6-sialyltransferase 1, Alpha 2, 6-ST 1, 2.4.99.1, B-cell antigen CD75, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 1, ST6Gal I, ST6GalI, Sialyltransferase 1, ST6GAL1, SIAT1 |
| Application Note | IHC~~1:100~500 IF~~1:50~200 FC~~1:10~50 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CDw75 (B-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST6GAL1 |
|---|---|
| Synonyms | SIAT1 |
| Function | Transfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates. In B lymphocytes, generates neuraminidase-sensitive lymphocyte cell-surface differentiation antigens, such as CDw75, HB-6 and CD76 (PubMed:1730763). |
| Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted {ECO:0000250|UniProtKB:P13721}. Note=Membrane-bound form in trans cisternae of Golgi (PubMed:20378551). Secreted into the body fluid (By similarity). {ECO:0000250|UniProtKB:P13721, ECO:0000269|PubMed:20378551} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Recognizes a neuraminidase-sensitive sialoprotein (CDw75), present on cell membrane and cytoplasm of germinal center B-cells and derived lymphomas. This MAb reacts with RBC precursors of bone marrow, ductal and ciliated epithelial cells of kidney, breast, prostate, pancreas, lung, and with glioblastomas, astrocytomas, and Reed Sternberg cells in lymphocyte predominant Hodgkin s disease. It is shown to be a helpful antibody for ascribing a B-cell phenotype in known lymphoid tissues.
References
Epstein AL et. al. J of Immunology 133: 1028-1036, 1984. | Marder RJ et. al. Lab Invest 52: 497-504, 1985. |
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