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Napsin A (Lung Adenocarcinoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone NAPSA/1238 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, FC |
|---|---|
| Primary Accession | O96009 |
| Other Accession | 9476, 512843 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG, kappa |
| Clone Names | NAPSA/1238 |
| Calculated MW | 37kDa |
| Gene ID | 9476 |
|---|---|
| Other Names | Napsin-A, 3.4.23.-, Aspartyl protease 4, ASP4, Asp 4, Napsin-1, TA01/TA02, NAPSA, NAP1, NAPA |
| Application Note | WB~~1:1000 IHC~~1:100~500 IF~~1:50~200 FC~~1:10~50 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Napsin A (Lung Adenocarcinoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NAPSA |
|---|---|
| Synonyms | NAP1, NAPA |
| Function | May be involved in processing of pneumocyte surfactant precursors. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
Napsin is a pepsin-like aspartic proteinase connected with maturation of surfactant protein B.ĀThere are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.
References
Bishop, JA et. al. Hum Pathol 41: 20-25 | Ordonez, NG 2012 Adv Anat Pathol 19: 66-73 | Ye, J et. al. Appl Immunhistochem Mol Morphol 19: 313-31
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