CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone TNFS7/1026 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-F, IF, FC, E, IP |
---|---|
Primary Accession | P32970 |
Other Accession | 970, 501497, 715224 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | Mouse / IgG1, kappa |
Clone Names | TNFS7/1026 |
Calculated MW | 30kDa |
Gene ID | 970 |
---|---|
Other Names | CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7 |
Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
Precautions | CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD70 |
---|---|
Synonyms | CD27L, CD27LG, TNFSF7 |
Function | Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. |
Cellular Location | Membrane; Single- pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis.
References
Lens, S.M., et al. 1995. CD27-CD70 interaction: unravelling its implication in normal and neoplastic B cell growth. Leuk. Lymphoma 18: 51-59
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