Cytokeratin, pan (Epithelial Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone KRTL/1077 + KRTH/1076 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IF, FC |
---|---|
Primary Accession | Q7Z794 |
Other Accession | 374454 (KRT77), 51350 (KRT76), Q01546 (KRT76)Unigene334989 (KRT77), 654392 (KRT76)Human Gene SymbolKRT77, KRT76Hu Chromosome Location17q21.2 (KRT77), 12q13.13 (KRT76)SynonymK1B, KRT1B, K77, CK-1B, Keratin 1B, Keratin-77, Cytokeratin-1B, KRT2B, KRT2P |
Reactivity | Human, Rat |
Host | Mouse |
Clonality | Monoclonal |
Isotype | Mouse / IgG's |
Clone Names | KRTL/1077 + KRTH/1076 |
Calculated MW | 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19) |
Gene ID | 374454 |
---|---|
Other Names | Keratin, type II cytoskeletal 1b, Cytokeratin-1B, CK-1B, Keratin-77, K77, Type-II keratin Kb39, KRT77, KRT1B |
Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
Precautions | Cytokeratin, pan (Epithelial Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KRT77 |
---|---|
Synonyms | KRT1B |
Tissue Location | Expressed exclusively in skin. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which include CK1, CK3, CK4, CK5, CK6, CK8, CK10, CK14, CK15, CK16, and CK19. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. KRTL/KRTH is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
References
Woodock-Mitchell J et. al. Journal of Cell Biology 1982;95:580-8.,2. Tseng SCG et. al. Cell 1982; 30361
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.