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Cytokeratin, Multi (Epithelial Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone KRT/457 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, FC |
|---|---|
| Primary Accession | P02538 |
| Other Accession | 3851 (CK4), 3852 (CK5), 3853 (CK6A), 3854 (CK6B), 286887 (CK6C), 3856 (CK8), 3858 (CK10), 3860 (CK13), 3875 (CK18) (Human), P04259 (CK6B), P13647 (CK5), P19013 (CK4), P48668 (CK6C) |
| Reactivity | Human, Mouse, Rat, Monkey, Pig, Goat, Bovine, Guinea Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1 |
| Clone Names | KRT/457 |
| Calculated MW | Multiple KDa |
| Gene ID | 3853 |
|---|---|
| Other Names | Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D |
| Application Note | WB~~1:1000 IHC-P~~N/A IF~~1:50~200 FC~~1:10~50 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Cytokeratin, Multi (Epithelial Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRT6A |
|---|---|
| Synonyms | K6A, KRT6D |
| Function | Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. |
| Tissue Location | Expressed in the corneal epithelium (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, including 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 53kDa (CK13) and 45kDa (CK18). This is a broad-spectrum antibody, which has been reported to differentiate epithelial tumors from non-epithelial tumors. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
References
Bartek J et. al. J Pathol, 1991, 164(3):215-24. ,Kasper M. Histochemistry, 1991, 95(6):613-20
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