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TSC22D4 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9Y3Q8 |
| Other Accession | NM_030935, NP_112197 |
| Reactivity | Human, Rat, Dog |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Gene ID | 81628 |
|---|---|
| Alias Symbol | THG1, THG-1, TILZ2 |
| Other Names | TSC22 domain family protein 4, TSC22-related-inducible leucine zipper protein 2, Tsc-22-like protein THG-1, TSC22D4, THG1, TILZ2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-TSC22D4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TSC22D4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSC22D4 (HGNC:21696) |
|---|---|
| Function | Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9EQN3}. Cytoplasm {ECO:0000250|UniProtKB:Q9EQN3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9EQN3}. Synapse {ECO:0000250|UniProtKB:Q9EQN3} Note=Localizes away from the nucleus to neurite processes and synaptic termini as cerebellar granular neurons differentiate (By similarity) Accumulates in the cytoplasm of differentiated Purkinje cells (By similarity). Localized to both the cytoplasm and nucleus in immature cerebellar granular neurons and atrophic Purkinje cells (By similarity). {ECO:0000250|UniProtKB:Q9EQN3} |
| Tissue Location | Expressed in the liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Scherer,S.W., et al., (2003) Science 300 (5620), 767-772Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Canterini, S., Bosco, A., De Matteis, V., Mangia, F. & Fiorenza, M. T. THG-1pit moves to nucleus at the onset of cerebellar granule neurons apoptosis. Mol. Cell. Neurosci. 40, 249-57 (2009). WB, Human, Guinea pig, Dog, Rat19084601Canterini, S. et al. Subcellular TSC22D4 localization in cerebellum granule neurons of the mouse depends on development and differentiation. Cerebellum 11, 28-40 (2012). WB, IHC, Human, Guinea pig, Dog, Rat20878296
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