ZBTB48 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P10074 |
Other Accession | NM_005341, NP_005332 |
Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Dog |
Predicted | Human, Mouse, Rat, Chicken, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 37kDa |
Gene ID | 3104 |
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Alias Symbol | HKR3, pp9964, ZNF855 |
Other Names | Zinc finger and BTB domain-containing protein 48, Krueppel-related zinc finger protein 3, Protein HKR3, Zinc finger protein 855, ZBTB48, HKR3, ZNF855 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ZBTB48 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | ZBTB48 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZBTB48 (HGNC:4930) |
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Function | Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). |
Cellular Location | Nucleus. Chromosome, telomere Note=Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411). According to another report, binds telomeres regardless of their length (PubMed:28500257) |
Tissue Location | Detected in adrenal gland and neuroblastoma. |
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Provided below are standard protocols that you may find useful for product applications.
References
Maris,J.M., (1996) Genomics 35 (2), 289-298Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Kim, K. et al. Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Mol. Cancer Ther. 11, 1852-62 (2012). WB, Human, Bovine, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse22752225
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