ECD antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O95905 |
Other Accession | NM_007265, NP_009196 |
Reactivity | Human, Mouse, Rat, Pig, Goat, Horse, Bovine, Dog |
Predicted | Human, Mouse, Pig, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 73kDa |
Gene ID | 11319 |
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Alias Symbol | GCR2, HSGT1 |
Other Names | Protein SGT1, hSGT1, Protein ecdysoneless homolog, Suppressor of GCR2, ECD, SGT1 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ECD antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | ECD antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ECD |
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Function | Regulator of p53/TP53 stability and function. Inhibits MDM2- mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). |
Cellular Location | Cytoplasm. Nucleus. Note=Predominantly is located in the cytoplasm. |
Tissue Location | Highly expressed in muscle and heart. Over- expressed in pancreatic and breast cancers |
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Provided below are standard protocols that you may find useful for product applications.
References
Olsen,J.V., (2006) Cell 127 (3), 635-648 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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