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ECD antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - ECD antibody - N-terminal region AI10449
    WB Suggested Anti-ECD Antibody Titration: .2-1 μg/ml
    ELISA Titer: 1:3125
    Positive Control: Jurkat cell lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O95905
Other Accession NM_007265, NP_009196
Reactivity Human, Mouse, Rat, Pig, Goat, Horse, Bovine, Dog
Predicted Human, Mouse, Pig, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 73kDa
Additional Information
Gene ID 11319
Alias Symbol GCR2, HSGT1
Other Names Protein SGT1, hSGT1, Protein ecdysoneless homolog, Suppressor of GCR2, ECD, SGT1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ECD antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsECD antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ECD
Function Regulator of p53/TP53 stability and function. Inhibits MDM2- mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
Cellular Location Cytoplasm. Nucleus. Note=Predominantly is located in the cytoplasm.
Tissue Location Highly expressed in muscle and heart. Over- expressed in pancreatic and breast cancers
Research Areas
Citations (0)
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References

Olsen,J.V., (2006) Cell 127 (3), 635-648 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

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$ 389.00
Cat# AI10449
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