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TBX5 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q99593 |
| Other Accession | NM_000192, NP_000183 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Pig, Goat, Sheep, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Zebrafish, Chicken, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58kDa |
| Gene ID | 6910 |
|---|---|
| Alias Symbol | HOS |
| Other Names | T-box transcription factor TBX5, T-box protein 5, TBX5 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TBX5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TBX5 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TBX5 |
|---|---|
| Function | DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation (PubMed:25725155, PubMed:25963046, PubMed:26917986, PubMed:27035640, PubMed:29174768, PubMed:8988164). Binds to the core DNA motif of NPPA promoter (PubMed:26926761). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201, ECO:0000269|PubMed:29174768}. Cytoplasm Note=Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Zaragoza,M.V., et al., (2004) Gene 330, 38978Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Publications:Lu, J. et al. Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos. J. Biomed. Sci. 18, 73 (2011). WB, Rat, Sheep, Goat, Human, Dog, Bovine, Pig, Horse, Rabbit, Guinea pig, Mouse, Zebrafish21982178Zhang, Y., Huang, L., Zuo, Z., Chen, Y. & Wang, C. Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. Aquat. Toxicol. 142-143, 26-32 (2013). WB, Rat, Sheep, Goat, Human, Dog, Bovine, Pig, Horse, Rabbit, Guinea pig, Mouse, Zebrafish23948075Baban, A. et al. Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: functional characterization of a de novo TBX5 mutation. Am. J. Med. Genet. A 164A, 1419-24 (2014). WB, Rat, Sheep, Goat, Human, Dog, Bovine, Pig, Horse, Rabbit, Guinea pig, Mouse, Zebrafish24664498
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