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Accn2 antibody - N-terminal region
Rabbit Polyclonal Antibody
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q6NXK8 |
| Other Accession | NM_009597, NP_033727 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60kDa |
| Gene ID | 11419 |
|---|---|
| Alias Symbol | AI843610, ASIC, ASIC1, ASIC1a, B530003N02Rik, BNaC2, Accn2 |
| Other Names | Acid-sensing ion channel 1, ASIC1, Acid-sensing ion channel, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2, BNaC2, Asic1, Accn2, Asic, Bnac2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Accn2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Accn2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Asic1 {ECO:0000312|MGI:MGI:1194915} |
|---|---|
| Function | Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:11988176, PubMed:12843249, PubMed:15369669, PubMed:17060608). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:15369669). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:15369669). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines (PubMed:15369669, PubMed:17060608). Modulates neuronal activity in the circuits underlying innate fear (PubMed:17662962). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P78348} Postsynaptic cell membrane. Cell projection, dendrite. Note=Isolated in synaptosomes from the dendritic synapses of neurons. |
| Tissue Location | Expressed in brain areas receiving strong excitatory corticofugal input. In hippocampus, expressed in the hilus of the dentate gyrus. In the cerebral cortex expressed in anterior and posterior cingulate cortex, sensory and motor cortices. In the sensory cortex strongest expression is detected in the whisker barrel field. In sensorimotor and cingulate cortex expression is elevated in layer III Also expressed in basal ganglia, striatum, ventral pallidum, olfactory tubercle, and nucleus accumbens. Weakly expressed in thalamus with the exception of the habenula and the medial septal nuclei. In olfactory bulb, preferentially expressed in the glomerular layer, within glomeruli. Expressed in cerebellum in the molecular and granule cell layers. Strongly expressed in amygdala complex, particularly in the lateral and basolateral nuclei. Isoform 1 is more abundant in brain compared to isoform 2 (at protein level). Expressed in the nodose ganglion and dorsal root ganglion. Expressed in dendritic spine cells |
Research Areas
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Application Protocols
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$ 389.00
Cat# AI10776
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