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L3MBTL antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9Y468 |
| Other Accession | NM_015478, NP_056293 |
| Reactivity | Human, Dog |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 86kDa |
| Gene ID | 26013 |
|---|---|
| Alias Symbol | DKFZp586P1522, FLJ41181, H-L(3)MBT, KIAA0681, L3MBTL1, dJ138B7.3, L3MBTL |
| Other Names | Lethal(3)malignant brain tumor-like protein 1, H-l(3)mbt, H-l(3)mbt protein, L(3)mbt-like, L(3)mbt protein homolog, L3MBTL1, L3MBTL1, KIAA0681, L3MBT, L3MBTL |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-L3MBTL antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | L3MBTL antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | L3MBTL1 |
|---|---|
| Synonyms | KIAA0681, L3MBT, L3MBTL |
| Function | Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53- target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys- 860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. |
| Cellular Location | Nucleus. Note=Excluded from the nucleolus. Does not colocalize with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex |
| Tissue Location | Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Min,J., (2007) Nat. Struct. Mol. Biol. 14 (12), 1229-1230 Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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$ 389.00
Cat# AI11307
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