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SC5DL antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O75845 |
| Other Accession | NM_001024956, NP_001020127 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35kDa |
| Gene ID | 6309 |
|---|---|
| Alias Symbol | ERG3, S5DES, SC5D, SC5DL |
| Other Names | Lathosterol oxidase, 1.14.21.6, C-5 sterol desaturase, Delta(7)-sterol 5-desaturase, Lathosterol 5-desaturase, Sterol-C5-desaturase, SC5D, SC5DL |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-SC5DL antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SC5DL antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SC5D (HGNC:10547) |
|---|---|
| Function | Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7- dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis (PubMed:10786622, PubMed:38297129). In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death (PubMed:38297129, PubMed:38297130). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Krakowiak,P.A.,(2003)Hum.Mol.Genet.12(13),1631-1641ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
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