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St6galnac1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9QZ39 |
| Other Accession | NM_011371, NP_035501 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61kDa |
| Gene ID | 20445 |
|---|---|
| Alias Symbol | Siat7a |
| Other Names | Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 1, 2.4.99.3, GalNAc alpha-2, 6-sialyltransferase I, ST6GalNAc I, ST6GalNAcI, Sialyltransferase 7A, SIAT7-A, St6galnac1, Siat7a |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-St6galnac1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | St6galnac1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | St6galnac1 {ECO:0000312|MGI:MGI:1341826} |
|---|---|
| Synonyms | Siat7a |
| Function | Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (PubMed:35303419). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:10788794). Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells (PubMed:35303419, PubMed:16207894). Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation (PubMed:35303419). |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NSC7}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9NSC7} |
| Tissue Location | Submaxillary gland, mammary gland, spleen and colon. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI12798
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