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POLRMT Antibody - C-terminal region
Rabbit Polyclonal Antibody
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O00411 |
| Other Accession | NM_005035, NP_005026 |
| Reactivity | Human, Mouse, Rat, Yeast, Bovine, Guinea Pig, Dog |
| Predicted | Human, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 135kDa |
| Gene ID | 5442 |
|---|---|
| Alias Symbol | APOLMT, MTRNAP, MTRPOL, h-mtRPOL |
| Other Names | DNA-directed RNA polymerase, mitochondrial, MtRPOL, 2.7.7.6, POLRMT |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-POLRMT antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | POLRMT Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POLRMT (HGNC:9200) |
|---|---|
| Function | DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). |
| Cellular Location | Mitochondrion |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI12927
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