FAM62B antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IP |
---|---|
Primary Accession | A0FGR8 |
Other Accession | NM_020728, NP_065779 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 99kDa |
Gene ID | 57488 |
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Alias Symbol | CHR2SYT, ESYT2, KIAA1228, E-Syt2, FAM62B |
Other Names | Extended synaptotagmin-2, E-Syt2, Chr2Syt, ESYT2, FAM62B, KIAA1228 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-FAM62B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | FAM62B antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ESYT2 (HGNC:22211) |
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Synonyms | FAM62B, KIAA1228 |
Function | Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). |
Cellular Location | Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437) |
Tissue Location | Widely expressed with high level in cerebellum. |
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Provided below are standard protocols that you may find useful for product applications.
References
Min S.-W.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:3823-3828(2007).
Shan Y.X.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.W.,et al.Science 300:767-772(2003).
Nagase T.,et al.DNA Res. 6:337-345(1999).
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