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PVRIG antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q6DKI7 |
| Other Accession | NM_024070, NP_076975 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34kDa |
| Gene ID | 79037 |
|---|---|
| Alias Symbol | C7orf15, MGC104322, MGC138295, MGC138297, MGC2463 |
| Other Names | Transmembrane protein PVRIG, Poliovirus receptor-related immunoglobulin domain-containing protein, PVRIG, C7orf15 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PVRIG antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | PVRIG antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PVRIG |
|---|---|
| Synonyms | C7orf15 |
| Function | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells |
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Provided below are standard protocols that you may find useful for product applications.
References
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Wilson M.D.,et al.Physiol. Genomics 27:201-218(2006).
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