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KCNK4 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NYG8 |
| Other Accession | NM_033310, NP_201567 |
| Reactivity | Human, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Rabbit, Pig, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43kDa |
| Gene ID | 50801 |
|---|---|
| Alias Symbol | K2p4.1, TRAAK, TRAAK1 |
| Other Names | Potassium channel subfamily K member 4, TWIK-related arachidonic acid-stimulated potassium channel protein, TRAAK, Two pore potassium channel KT4.1, Two pore K(+) channel KT4.1, KCNK4, TRAAK |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-KCNK4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | KCNK4 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNK4 {ECO:0000303|Ref.2, ECO:0000312|HGNC:HGNC:6279} |
|---|---|
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, heat and lipids (PubMed:22282805, PubMed:25471887, PubMed:25500157, PubMed:26919430, PubMed:30290154, PubMed:38605031). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:26919430). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (By similarity). Permeable to other monovalent cations such as Rb(+) and Cs(+) (PubMed:26919430). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:G3V8V5}. Note=Localizes at the Ranvier nodes of myelinated afferent nerves {ECO:0000250|UniProtKB:G3V8V5} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Chapman C.G.,et al.Brain Res. Mol. Brain Res. 82:74-83(2000).
Gray A.T.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Lesage F.,et al.FEBS Lett. 471:137-140(2000).
Ozaita A.,et al.Brain Res. Mol. Brain Res. 102:18-27(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
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$ 389.00
Cat# AI13141
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