Ik Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9Z1M8 |
Other Accession | NM_011879, NP_036009 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 65kDa |
Gene ID | 24010 |
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Alias Symbol | MuRED |
Other Names | Protein Red, Cytokine IK, IK factor, Protein RER, Ik, Red, Rer |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ik antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Ik Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Ik |
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Synonyms | Red, Rer |
Function | Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q13123}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q13123}. Chromosome {ECO:0000250|UniProtKB:Q13123}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q13123}. Note=Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase. {ECO:0000250|UniProtKB:Q13123} |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
References
Assier E.,et al.Gene 230:145-154(1999).
Trinidad J.C.,et al.Mol. Cell. Proteomics 5:914-922(2006).
Park J.,et al.Mol. Cell 50:919-930(2013).
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