Dusp7 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q63340 |
Other Accession | XM_238551, XP_238551 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 31kDa |
Gene ID | 300980 |
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Alias Symbol | mkp-X |
Other Names | Dual specificity protein phosphatase 7, 3.1.3.16, 3.1.3.48, Dual specificity protein phosphatase MKP-X, Dusp7, Mkpx |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Dusp7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Dusp7 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Dusp7 {ECO:0000312|RGD:735026} |
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Function | Dual specificity protein phosphatase (By similarity). Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q16829}. |
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Provided below are standard protocols that you may find useful for product applications.
References
Muda M.,et al.J. Biol. Chem. 271:4319-4326(1996).
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