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ANKRD9 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q96BM1 |
| Other Accession | NM_152326, NP_689539 |
| Reactivity | Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34kDa |
| Gene ID | 122416 |
|---|---|
| Alias Symbol | MGC21990 |
| Other Names | Ankyrin repeat domain-containing protein 9, ANKRD9 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ANKRD9 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ANKRD9 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ANKRD9 |
|---|---|
| Function | Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:30293565). Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly (PubMed:30293565, PubMed:31337707). Implicated in different cellular processes, like copper homeostasis and cell proliferation (PubMed:24522796, PubMed:30293565). |
| Cellular Location | Cytoplasmic vesicle. Cytoplasm, cytosol Note=Detected in long filamentous cytosolic structures where it colocalizes with IMPDH2 (PubMed:31337707). Under basal conditions ANKRD9 is mainly in vesicle-like structures, upon nutrient limitation (guanine nucleotides deficiency) ANKRD9 loses its vesicular pattern and assembles with IMPDH2 into rodlike filaments (PubMed:31337707) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Li W.B.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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