Usp21 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9QZL6 |
Other Accession | NM_013919, NP_038947 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 62kDa |
Gene ID | 30941 |
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Alias Symbol | ESTM28, Usp16, Usp23, W53272 |
Other Names | Ubiquitin carboxyl-terminal hydrolase 21, 3.4.19.12, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific-processing protease 21, Usp21, Usp23 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Usp21 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Usp21 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Usp21 {ECO:0000303|PubMed:18172164, ECO:0000312|MGI:MGI:1353665} |
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Function | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator (PubMed:18172164). Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation (PubMed:18172164). Regulates gene expression via histone H2A deubiquitination (PubMed:18172164). Deubiquitinates BAZ2A/TIP5 leading to its stabilization (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (By similarity). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (By similarity). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9UK80}. Nucleus {ECO:0000250|UniProtKB:Q9UK80} |
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Provided below are standard protocols that you may find useful for product applications.
References
Smith T.S.,et al.Biochim. Biophys. Acta 1490:184-188(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Nakagawa T.,et al.Genes Dev. 22:37-49(2008).
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