PELI1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q8C669 |
Other Accession | NM_020651, NP_065702 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46kDa |
Gene ID | 67245 |
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Alias Symbol | DKFZp686C18116, MGC50990 |
Other Names | E3 ubiquitin-protein ligase pellino homolog 1, Pellino-1, 6.3.2.-, Peli1 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PELI1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | PELI1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Peli1 |
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Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:16951688). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (By similarity). |
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Provided below are standard protocols that you may find useful for product applications.
References
Resch K.,et al.Cytogenet. Cell Genet. 92:172-174(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Choi K.C.,et al.Nat. Immunol. 7:1057-1065(2006).
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