Register or Login
All
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   PKM2 antibody - middle region   

PKM2 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - PKM2 antibody - middle region AI14197

    WB Suggested Anti-PKM2 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: Human heart
  • WB - PKM2 antibody - middle region AI14197

    Host:Rabbit
    Target Name:PKM
    Sample Tissue:Human Hela
    Antibody Dilution: 1.0μg/mlPKM is supported by BioGPS gene expression data to be expressed in HeLa
  • WB - PKM2 antibody - middle region AI14197

    Host:Rabbit
    Target Name:PKM
    Sample Tissue:Human Fetal Lung
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P11980
Other Accession NM_002654, NP_002645
Reactivity Human, Mouse, Rat, Rabbit, Sheep, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Rat, Pig, Chicken, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 58kDa
Additional Information
Gene ID 25630
Alias Symbol CTHBP, MGC3932, OIP3, PK3, PKM, TCB, THBP1, PKM2
Other Names Pyruvate kinase PKM, 2.7.1.40, Pyruvate kinase muscle isozyme, Pkm, Pkm2, Pykm
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-PKM2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPKM2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pkm
Synonyms Pkm2, Pykm
Function Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. In addition to its role in glycolysis, also regulates transcription. Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1- dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages. Also acts as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum- destined mRNAs (By similarity). Plays a general role in caspase independent cell death of tumor cells (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P14618}. Nucleus {ECO:0000250|UniProtKB:P14618}. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform- specific and independent of its enzymatic activity {ECO:0000250|UniProtKB:P14618}
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.

References

Noguchi T.,et al.J. Biol. Chem. 261:13807-13812(1986).
Takenaka M.,et al.J. Biol. Chem. 264:2363-2367(1989).
Parkinson C.,et al.Nucleic Acids Res. 17:7106-7106(1989).
Lubec G.,et al.Submitted (JUL-2007) to UniProtKB.

FeedBack
Abcepta welcomes feedback from its customers.

If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at tech@abcepta.com.

$ 389.00
Cat# AI14197
Size:
Quantity:
Availability: 2-3 days
Bulk Size

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abcepta, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900
Cedarlane Labs
+1 (800) 721-1644
+1 (336) 513-5138

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Terms & Conditions
"