PKM2 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P11980 |
Other Accession | NM_002654, NP_002645 |
Reactivity | Human, Mouse, Rat, Rabbit, Sheep, Horse, Yeast, Bovine, Guinea Pig, Dog |
Predicted | Human, Rat, Pig, Chicken, Horse, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 58kDa |
Gene ID | 25630 |
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Alias Symbol | CTHBP, MGC3932, OIP3, PK3, PKM, TCB, THBP1, PKM2 |
Other Names | Pyruvate kinase PKM, 2.7.1.40, Pyruvate kinase muscle isozyme, Pkm, Pkm2, Pykm |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-PKM2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | PKM2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Pkm |
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Synonyms | Pkm2, Pykm |
Function | Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. |
Cellular Location | [Isoform M2]: Cytoplasm {ECO:0000250|UniProtKB:P14618}. Nucleus {ECO:0000250|UniProtKB:P14618} Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli {ECO:0000250|UniProtKB:P14618} |
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Provided below are standard protocols that you may find useful for product applications.
References
Noguchi T.,et al.J. Biol. Chem. 261:13807-13812(1986).
Takenaka M.,et al.J. Biol. Chem. 264:2363-2367(1989).
Parkinson C.,et al.Nucleic Acids Res. 17:7106-7106(1989).
Lubec G.,et al.Submitted (JUL-2007) to UniProtKB.
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