|Other Accession||NM_001111119, NP_001104589|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||Gm288, Hei10, mei4|
|Other Names||E3 ubiquitin-protein ligase CCNB1IP1, 6.3.2.-, Cyclin-B1-interacting protein 1, Ccnb1ip1, Gm288, Hei10, Mei4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Ccnb1ip1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Ccnb1ip1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Gm288, Hei10, Mei4|
|Function||Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non- crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.|
|Cellular Location||Nucleus. Chromosome. Note=Associates to the synaptonemal complex|
|Tissue Location||Expressed predominantly in the testes and 17 day embryos (corresponding to prophase I in females). Weakly or not expressed in other tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ward J.O.,et al.PLoS Genet. 3:E139-E139(2007).
Strong E.R.,et al.Genes (Basel) 1:440-451(2010).
Qiao H.,et al.Nat. Genet. 46:194-199(2014).
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