Wipf1 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q6IN36 |
Other Accession | NM_057192, NP_476540 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 53kDa |
Gene ID | 117538 |
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Alias Symbol | Waspip, Wip |
Other Names | WAS/WASL-interacting protein family member 1, Wiskott-Aldrich syndrome protein-interacting protein, WASP-interacting protein, Wipf1, Waspip, Wip |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Wipf1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Wipf1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Wipf1 |
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Synonyms | Waspip, Wip |
Function | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. Plays a role in the formation of cell ruffles (By similarity). May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. |
Cellular Location | Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL |
Tissue Location | Isoforms were differentially expressed. One isoform was ubiquitously expressed, another was muscle-specific and another was expressed in the liver, heart and testis |
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Provided below are standard protocols that you may find useful for product applications.
References
Vetterkind S.,et al.J. Biol. Chem. 277:87-95(2002).
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