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>   home   >   Products   >   Primary Antibodies   >   Eif4e antibody - C-terminal region   

Eif4e antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - Eif4e antibody - C-terminal region AI14335

    WB Suggested Anti-Eif4e Antibody Titration: 1.0 μg/ml
    Positive Control: Rat Liver
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P63074
Other Accession NM_053974, NP_446426
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Pig, Chicken, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 25kDa
Additional Information
Gene ID 117045
Alias Symbol MGC93265
Other Names Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, Eif4e
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Eif4e antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsEif4e antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Eif4e
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:7939721). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:8558852). Component of the CYFIP1- EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (PubMed:8558852).
Cellular Location Cytoplasm, P-body {ECO:0000250|UniProtKB:P06730}. Cytoplasm {ECO:0000250|UniProtKB:P06730}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P06730}. Nucleus {ECO:0000250|UniProtKB:P06730} Note=Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies). Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism {ECO:0000250|UniProtKB:P06730}
Tissue Location Very high levels in post-meiotic testicular germ cells of rats of reproductive age.
Citations (0)

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References

Miyagi Y.,et al.Lab. Invest. 73:890-898(1995).
Lin T.-A.,et al.Science 266:653-656(1994).

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$ 389.00
Cat# AI14335
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