Nfatc2 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q60591 |
Other Accession | NM_001037178, NP_001032255 |
Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 49kDa |
Gene ID | 18019 |
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Alias Symbol | AI607462, NFAT1, NFAT1-D, Nfatp, NF-ATc2 |
Other Names | Nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFATc2, NFAT pre-existing subunit, NF-ATp, T-cell transcription factor NFAT1, Nfatc2, Nfat1, Nfatp |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Nfatc2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Nfatc2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Nfatc2 |
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Synonyms | Nfat1, Nfatp |
Function | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (By similarity). Is involved in the negative regulation of chondrogenesis (PubMed:10620601). |
Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin- mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription |
Tissue Location | Expressed in spleen, heart, testis, brain, placenta, muscle and pancreas (PubMed:18675896). Expressed in the thymus (PubMed:18675896, PubMed:17579027). Expressed in the lung (PubMed:17579027). Expressed in cartilage (PubMed:10620601) |
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Provided below are standard protocols that you may find useful for product applications.
References
McCaffrey P.G.,et al.Science 262:750-754(1993).
Luo C.,et al.Mol. Cell. Biol. 16:3955-3966(1996).
Plyte S.,et al.J. Biol. Chem. 276:14350-14358(2001).
Vihma H.,et al.Genomics 92:279-291(2008).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
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