|Other Accession||NM_001037178, NP_001032255|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||AI607462, NFAT1, NFAT1-D, Nfatp, NF-ATc2|
|Other Names||Nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFATc2, NFAT pre-existing subunit, NF-ATp, T-cell transcription factor NFAT1, Nfatc2, Nfat1, Nfatp|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Nfatc2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Nfatc2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin- mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription|
|Tissue Location||Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
McCaffrey P.G.,et al.Science 262:750-754(1993).
Luo C.,et al.Mol. Cell. Biol. 16:3955-3966(1996).
Plyte S.,et al.J. Biol. Chem. 276:14350-14358(2001).
Vihma H.,et al.Genomics 92:279-291(2008).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
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