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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Reck antibody - middle region   

Reck antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - Reck antibody - middle region AI14370

    WB Suggested Anti-Reck Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Spleen
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9Z0J1
Other Accession NM_016678, NP_057887
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 104kDa
Additional Information
Gene ID 53614
Alias Symbol MGC169689, St15, mRECK
Other Names Reversion-inducing cysteine-rich protein with Kazal motifs, mRECK, Reck
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Reck antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsReck antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Reck {ECO:0000303|PubMed:9789069, ECO:0000312|MGI:MGI:1855698}
Function Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28803732). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:26658478, PubMed:28803732). Acts as a Wnt7- specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (By similarity). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:11747814). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:11747814).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:O95980}
Research Areas
Citations (0)

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References

Takahashi C.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:13221-13226(1998).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).

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$ 389.00
Cat# AI14370
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