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Ubxn6 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Ubxn6 antibody - middle region AI14378

    WB Suggested Anti-Ubxn6 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Heart
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99PL6
Other Accession NM_024432, NP_077752
Reactivity Human, Mouse, Rat, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Chicken, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Additional Information
Gene ID 66530
Alias Symbol 1200008L11Rik, 2210415J11Rik, AU040909, Ubxd1, Ubxdc2
Other Names UBX domain-containing protein 6, UBX domain-containing protein 1, Ubxn6, Ubxd1, Ubxdc2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Ubxn6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsUbxn6 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ubxn6 {ECO:0000312|MGI:MGI:1913780}
Function May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9BZV1}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BZV1}. Membrane {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BZV1}. Nucleus {ECO:0000250|UniProtKB:Q9BZV1} Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9BZV1}. Early endosome membrane {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BZV1}. Late endosome membrane {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BZV1}. Lysosome membrane {ECO:0000250|UniProtKB:Q9BZV1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BZV1}. Note=Localizes at the centrosome both in interphase and during mitosis. May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. {ECO:0000250|UniProtKB:Q9BZV1}
Tissue Location Widely expressed (at protein level). Highest expression in brain (at protein level).
Research Areas
Citations (0)

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Carim-Todd L.,et al.Biochim. Biophys. Acta 1517:298-301(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Madsen L.,et al.Int. J. Biochem. Cell Biol. 40:2927-2942(2008).

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$ 389.00
Cat# AI14378
Availability: 2-3 days
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