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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   UBL4A antibody - middle region   

UBL4A antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - UBL4A antibody - middle region AI14388

    WB Suggested Anti-UBL4A Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: Jurkat cell lysate
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession B7NZQ9
Other Accession NM_014235, NP_055050
Reactivity Human, Mouse, Rat, Rabbit, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 18kDa
Additional Information
Gene ID 100328764
Alias Symbol DX254E, DXS254E, G6PD, GDX, UBL4, GET5, MDY2, TMA24
Other Names Ubiquitin-like protein 4A, UBL4A
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-UBL4A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsUBL4A antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBL4A
Function As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:P11441}. Nucleus {ECO:0000250|UniProtKB:P11441}
Research Areas
Citations (0)

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References

Antonellis A.,et al.Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.

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$ 389.00
Cat# AI14388
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