|Other Accession||NM_006336, NP_006327|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Dog|
|Alias Symbol||C9orf60, Hzyg, RP11-545E17.4, ZYG, ZYG11BL|
|Other Names||Protein zer-1 homolog, Hzyg, Zyg-11 homolog B-like protein, ZER1, C9orf60, ZYG, ZYG11BL|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ZER1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ZER1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC (PubMed:17304241, PubMed:31273098). Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation (PubMed:31273098).|
|Tissue Location||Expressed in testis, spermatocytes and spermatids (at protein level). Expressed in spermatocytes, spermatids, prostate, skeletal muscle, ovary, small intestine, heart, brain and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Feral C.,et al.Mol. Hum. Reprod. 7:1115-1122(2001).
Humphray S.J.,et al.Nature 429:369-374(2004).
Vasudevan S.,et al.EMBO Rep. 8:279-286(2007).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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