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Vamp8 antibody - middle region

Rabbit Polyclonal Antibody

  • WB - Vamp8 antibody - middle region AI14416

    WB Suggested Anti-Vamp8 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Small Intestine
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O70404
Other Accession NM_016794, NP_058074
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 11kDa
Additional Information
Gene ID 22320
Alias Symbol AU041171, Edb, endobrevin
Other Names Vesicle-associated membrane protein 8, VAMP-8, Endobrevin, Edb, Vamp8
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Vamp8 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsVamp8 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Vamp8 {ECO:0000312|MGI:MGI:1336882}
Function SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex (By similarity). Also required for dense-granule secretion in platelets (By similarity). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (PubMed:15363411). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (By similarity).
Cellular Location Lysosome membrane; Single-pass type IV membrane protein. Late endosome membrane {ECO:0000250|UniProtKB:Q9WUF4}; Single-pass type IV membrane protein. Early endosome membrane {ECO:0000250|UniProtKB:Q9WUF4}; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans- Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells (By similarity). Midbody region during cytokinesis (By similarity). Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells; in zymogen granule membranes (PubMed:9614193) {ECO:0000250|UniProtKB:Q9WUF4, ECO:0000269|PubMed:9614193}
Tissue Location Expressed abundantly in the kidney, less in the liver, brain, kidney, heart, lung, pancreas and placenta
Research Areas
Citations (0)

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Wong S.H.,et al.Mol. Biol. Cell 9:1549-1563(1998).
Advani R.J.,et al.J. Biol. Chem. 273:10317-10324(1998).
Lu L.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Wang C.-C.,et al.Dev. Cell 7:359-371(2004).

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$ 389.00
Cat# AI14416
Availability: 2-3 days
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